Author: Isabel Juliana Hofman

Vaccine-assisting molecules help the lung memorize immune responses

Traditional vaccines are generally better at eliciting antibody responses rather than building a memory of cellular immunity involving dedicated T cell subsets. Vaccines directed towards infections such as HIV or cancers would be vastly improved if they could elicit these responses more efficiently. New research uncovers a mechanism to establish such a memory in the lung which is conserved in mice, non-human primates and humans.… Read More Vaccine-assisting molecules help the lung memorize immune responses

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Sometimes more is more: raising mitochondrial DNA copy number could treat disease

Mitochondria are the power plants of our cells and are descendants of cooperating bacteria. A study in mice shows that increasing the copies of mitochondria’s own DNA could be used as therapy for certain human diseases. Isabel Hofman Mitochondria are the power plants of eukaryotic cells, as the mitochondrial respiratory electron transport chain serves as… Read More Sometimes more is more: raising mitochondrial DNA copy number could treat disease

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X marks the spot: new proteomic technique pinpoints protein locations

A new mass spectrometry based technique can be used to map the location of thousands of proteins in the cell simultaneously, shedding light on different proteomic cell states in health and disease. Isabel Hofman The omics era has made analysis of total genomes or transcriptomes to answer diverse scientific questions routine. However, while the proteome… Read More X marks the spot: new proteomic technique pinpoints protein locations

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